Disuse-induced muscle wasting

Prevention of Skeletal Muscle Wasting: Disuse Atrophy and Sarcopenia

Skeletal muscle plays a considerable role in health and disease. Muscle mass is essential for health and survival and plays a major role in mobility as well as morbidity and mortality. There is continual synthesis and degradation of proteins as part of normal metabolism and homeostasis. Equally remarkable, is the characteristic of plasticity allowing muscle to change and adapt depending on the ...

Extracellular Matrix and Gelatinases in Disuse-induced Skeletal Muscle Atrophy

+Liu, X.; Lee, D., Natsuhara K., Kim, H. +University of California, San Francisco, CA, Veterans Affairs Medical Center, San Francisco, CA Senior author: [email protected] INTRODUCTION: Extracellular matrix (ECM) plays a critical role in maintaining normal structure and function of skeletal muscle. Muscle basement membrane serves as an interface between cells and the rest of matrix. It is ...

Disuse TWEAKs muscle loss

Effect of denervation-induced muscle disuse on mitochondrial protein import.

This study determined whether muscle disuse affects mitochondrial protein import and whether changes in protein import are related to mitochondrial content and function. Protein import was measured using a model of unilateral peroneal nerve denervation in rats for 3 (n = 10), 7 (n = 12), or 14 (n = 14) days. We compared the import of preproteins into the matrix of subsarcolemmal (SS) and interm...

Muscle Deconditioning and Disuse Atrophy

Lack of physical activity can cause a muscle to atrophy. Muscle deconditioning may become apparent within days to weeks of decreased physical activity. For example, we have all known individuals who were physically fit during their high school days and then became less active over time. The cessation of regular activity causes the muscles to decrease in size, but contrary to what some people sa...